Beilstein J. Nanotechnol.2015,6, 414–419, doi:10.3762/bjnano.6.41
uptake of nanoparticles. Here, we present a versatile microfluidic device based on acousticstreaming induced by surface acoustic waves (SAWs). The device offers a convenient method for introducing fluid motion in standard cell culture chambers and for mimicking capillary blood flow. We show that shear
physiological flow conditions the particle uptake rates for this system are significantly lower than at low shear conditions. This underlines the vital importance of the fluidic environment for cellular uptake mechanisms.
Keywords: acousticstreaming; cellular uptake; flow; nanoparticles; sedimentation; shear
to the aforementioned problems is to perform experiments under realistic flow conditions. In the following, we introduce a novel device for inducing high shear rates at the bottom of an arbitrary cell culture chamber. The device is based on SAW-driven acousticstreaming. Many different applications
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Figure 1:
The uptake of particles by a cell is influenced by different factors: diffusion and sedimentation w...